effect of withania somnifera (l.) dunal on sex hormone and gonadotropin levels in addicted male rats
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abstract
objective: opioid consumption has been widely increasing across the globe; however, it can cause adverse effects on the body. morphine, an opioid, can reduce sex hormones and fertility. withania somnifera (ws) is a traditional herb used to improve sexual activities. this study strives to investigate the effect of ws on sex hormones and gonadotropins in addicted male rats. materials and methods: in this experimental study, forty-eight male national maritime research institute (nmri) rats were randomly divided into four groups: i. control group, ii. ws-treated control group, iii. addicted group, and iv. ws-treated addicted group. water- soluble morphine was given to rats for 21 days to induce addiction, concurrently the treated groups (2 and 4) also received ws plant-mixed pelleted food (6.25%). at the end of the treatment, the sex hormone and gonadotropin levels of the rats’ sera were determined in all the groups. results: except for follicle-stimulating hormone (fsh), morphine reduced most of the gonadotropin and sex hormone levels. whereas ws caused a considerable increase in the hormones in the treated addicted group, there was only a slight increase in the treated control group. conclusion: ws increased sex hormones and gonadotropins-especially testosterone, estrogen, and luteinizing hormone-in the addicted male rats and even increased the progesterone level, a stimulant of most sex hormones in addicted male rats.
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Effect of Withania somnifera (L.) Dunal on Sex Hormone and Gonadotropin Levels in Addicted Male Rats
Objective Opioid consumption has been widely increasing across the globe; however, it can cause adverse effects on the body. Morphine, an opioid, can reduce sex hormones and fertility. Withania somnifera (WS) is a traditional herb used to improve sexual activities. This study strives to investigate the effect of WS on sex hormones and gonadotropins in addicted male rats. MaterialsAndMethods In ...
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Journal title:
international journal of fertility and sterilityجلد ۱۰، شماره ۲، صفحات ۲۳۹-۲۴۴
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